Silibinin reduces cell proliferation and migration via EMT pathway in TFK-1 cell line

Autor: Özel Yetkin Merve, Baskol Gulden
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Türk Biyokimya Dergisi, Vol 48, Iss 6, Pp 709-717 (2023)
Druh dokumentu: article
ISSN: 1303-829X
DOI: 10.1515/tjb-2022-0270
Popis: Cholangiocarcinoma (CCA) is usually diagnosed at a late stage due to resistance to chemotherapeutic drugs. Epithelial mesenchymal transition (EMT) is a biological process in cancer that allows multiple biochemical changes that enable epithelial cells to acquire a mesenchymal phenotype. In the present study, we focused on the EMT process which is an important in carcinogenesis and metastatic progression, and also investigate the effect of silibinin on cell proliferation, colony formation, migration, apoptosis, cell cycle and EMT.
Databáze: Directory of Open Access Journals