The level of endothelin-1 and reactivity of skin microvessels in patients with early stages of chronic kidney disease
| Autor: | Aleksey Vladimirovich Smirnov, Nikolay Nikolaevich Petrishchev, Iraida Yur'evna Panina, Marina Mikhaylovna Mnuskina, Vera Vladimirovna Achkasova, Aleksandr Shalikovich Rumyantsev, Mariya Alekseevna Menshutina, A V Smirnov, N N Petrischev, I Yu Panina, M M Mnuskina, V V Achkasova, A Sh Rumyantsev, M A Menshutina |
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| Jazyk: | ruština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 83, Iss 6, Pp 13-18 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To evaluate endothelin-1 (ET-1) levels and to characterize reflex vasomotor reactions of skin vessels in distant exposure to cold in patients with chronic kidney disease (CKD) of stage I and II. Material and methods. Glomerular filtration rate (GFR) was calculated by MDRD formula for 40 healthy subjects (mean age 39.2±2.0 years) and 147 CKD patients (mean age 41.4±1.8 years). All the patients were also exposed to the cold test (a modified variant). Results. Patients with CKD stage I demonstrated a 35.1% fall in blood flow rate (Qas) in response to cold stimulus, patients of stage II - a 42.2% fall, healthy patients - a 19.3%. CKD patients of stage I and II retained a Qas fall for 3 min after exposure to cold, while healthy subjects resumed skin blood circulation immediately after exposure to cold. Blood plasma ET-1 concentration in healthy subjects was 0.239±0.055 fmol/ml, in stage I CKD patients - 0.334±0.066 fmol/l, in stage II CKD patients - 0.422±0.041 fmol/l. Relationships were found between ET-1 level and GFR (Rs = 0.242; p < 0.05), 24 h proteinuria (Rs = 0.375; p < 0.003) and Qas% in the cold test (Rs = -0.389; p < 0.003) as well as time of recovery of the background Qas (Rs = -0.311; p < 0.003). Conclusion. Dysfunction of autonomic nervous system at early stages of CKD may arise by means of activation of ET-1 synthesis in response to enhancement of sympathetic impacts. |
| Databáze: | Directory of Open Access Journals |
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