| Autor: |
Eriko Fujimoto, Tomohiro Yano, Hiromi Sato, Kiyokazu Hagiwara, Hiroshi Yamasaki, Sumiko Shirai, Keiko Fukumoto, Hiromi Hagiwara, Etsuko Negishi, Koichi Ueno |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 97, Iss 2, Pp 294-298 (2005) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.scj04009x |
| Popis: |
We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis. Keywords:: connexin 32, PKI-166, renal cancer cell |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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