Prevention of Antigen-Induced Bronchial Hyperreactivity and Airway Inflammation in Sensitized Guinea-Pigs by Tacrolimus

Autor: J. R. Lapa e Silva, C. Ruffié, J. Lefort, M-A. Nahori, B. B. Vargaftig, M. Pretolani
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Zdroj: Mediators of Inflammation, Vol 8, Iss 1, Pp 17-23 (1999)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
DOI: 10.1080/09629359990676
Popis: We examined the effect of the immunosuppressive agent, tacrolimus (FK506), on antigen-induced bronchial hyperreactivity to acetylcholine and leukocyte infiltration into the airways of ovalbumin-challenged guinea-pigs. Subcutaneous injection of 0.5 mg/kg of FK506, 1 h before and 5 h after intra-nasal antigen challenge prevented bronchial hyperreactivity to aerosolized acetylcholine, eosinophilia in bronchoalveolar lavage (BAL) fluid and bronchial tissue and the invasion of the bronchial wall by CD4+ T-lymphocytes. FK506 also suppressed ovalbumininduced increase in the number of leukocytes adhering to the pulmonary vascular endothelium and expressing α4-integrins. Inhibition by FK506 of antigen-induced bronchial hyperreactivity in sensitized guinea-pigs may thus relate to its ability to prevent the emergence of important inflammatory components of airway inflammation, such as eosinophil accumulation, as well as CD4+ T-lymphocyte infiltration into the bronchial tissue.
Databáze: Directory of Open Access Journals
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