| Autor: |
Ritu Nehra, Sandeep Grover, Deepak Chetri, Archana Sood, Chandi P Das |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Indian Journal of Psychological Medicine, Vol 34, Iss 4, Pp 376-380 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
0253-7176 |
| DOI: |
10.4103/0253-7176.108225 |
| Popis: |
Aim: To assess the P300 latency and amplitude in recently diagnosed human immunodeficiency virus (HIV)-positive patients and compare the same with a healthy control group. Further an attempt was made to study the correlation between P300 amplitude and latency (in milliseconds) with neurocognitive functions. Materials and Methods: Thirty newly diagnosed HIV-positive patients who on self report did not have any cognitive dysfunction were recruited. The patients were evaluated for P300 evoked response using the odd-ball paradigm, MMSE and a comprehensive neuropsychological battery. The P300 latencies were compared with 30 normal control subjects. Results: The mean P300 latency (in milliseconds) of the HIV-positive subjects was significantly more than the healthy control group. The mean amplitude of HIV group was significantly less than the normal control group. On MMSE, 7 HIV-positive subjects had mild cognitive impairment (MMSE total score 20-23), six patients had minimal cognitive impairment (MMSE total score 24-27) and 17 patients had no cognitive impairment (MMSE total score >27). On neuropsychological test battery only three (10%) of HIV-positive subjects had cognitive dysfunction. There was negative correlation between P300 latency (in milliseconds) and MMSE total score and performance on Koh′s Block subtest. Conclusion: P300 may be a reliable indicator of cognitive impairments in HIV patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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