A peculiar distribution on 18F-DCFPyL-PSMA PET scan for a patient with prostate cancer and protein S deficiency

Autor: Vaisnavi Thirugnanasundralingam, Shannon McGrath, Jay Roberts, Niall Corcoran
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Radiology Case Reports, Vol 19, Iss 10, Pp 4122-4126 (2024)
Druh dokumentu: article
ISSN: 1930-0433
81242468
DOI: 10.1016/j.radcr.2024.06.021
Popis: A 54-year-old male with biopsy-confirmed Gleason 4+4 prostate cancer underwent 18F-DCFPyL-PSMA PET scan to identify occult metastatic disease. This scan revealed abnormal radionuclide uptake not only in the prostate but also within the patient's vasculature. The scan was repeated after a week with a separate tracer batch, yielding the same result. Standard staging was performed using computed tomography and a Technetium-99 bone scan, revealing no metastatic disease. The patient's protein S deficiency is thought to have caused this peculiar tracer distribution. With the advent of PSMA PET for staging in prostate cancer, clinicians must be familiar with situations that may render unusual results.
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