Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review

Autor: Jorge A. M. Pereira, Priscilla Porto-Figueira, Ravindra Taware, Pritam Sukul, Srikanth Rapole, José S. Câmara
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecules, Vol 25, Iss 13, p 3098 (2020)
Druh dokumentu: article
ISSN: 25133098
1420-3049
DOI: 10.3390/molecules25133098
Popis: Fostered by the advances in the instrumental and analytical fields, in recent years the analysis of volatile organic compounds (VOCs) has emerged as a new frontier in medical diagnostics. VOCs analysis is a non-invasive, rapid and inexpensive strategy with promising potential in clinical diagnostic procedures. Since cellular metabolism is altered by diseases, the resulting metabolic effects on VOCs may serve as biomarkers for any given pathophysiologic condition. Human VOCs are released from biomatrices such as saliva, urine, skin emanations and exhaled breath and are derived from many metabolic pathways. In this review, the potential of VOCs present in saliva will be explored as a monitoring tool for several oral diseases, including gingivitis and periodontal disease, dental caries, and oral cancer. Moreover, the analytical state-of-the-art for salivary volatomics, e.g., the most common extraction techniques along with the current challenges and future perspectives will be addressed unequivocally.
Databáze: Directory of Open Access Journals
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