Gene expression of adipokines and inflammatory cytokines in peripheral blood mononuclear cells of obese dogs

Autor:	Seo‐Young Hwang, Ju‐Hyun An, Kyung‐Bo Kim, Jeong‐Hwa Lee, Su‐Min Park, Ye‐in Oh, Hyung Kyu Chae, Hwa‐Young Youn
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	adipokine canine obesity peripheral blood mononuclear cell pro‐inflammatory cytokine Veterinary medicine SF600-1100
Zdroj:	Veterinary Medicine and Science, Vol 8, Iss 2, Pp 517-523 (2022)
Druh dokumentu:	article
ISSN:	2053-1095
DOI:	10.1002/vms3.713
Popis:	Abstract Background Peripheral blood mononuclear cells (PBMCs) have been identified as a possible marker of inflammation in obesity. Understanding the expression of pro‐ and anti‐inflammatory cytokines in PBMCs in obese dogs will help control obesity‐related inflammatory diseases. Objectives The aim of this study was to evaluate the role of PBMCs in obesity‐associated chronic inflammation by analyzing the expression of adipokines and inflammatory cytokines. Methods Blood samples were obtained from 25 subjects and real‐time quantitative polymerase chain reaction determinations were performed to quantify the gene expression levels of adipokines and inflammatory cytokines, including TNF‐α, IL‐17, leptin, MCP‐1, and adiponectin, in the PBMCs. Results The results showed that the gene expression levels of TNF‐α (p
Databáze:	Directory of Open Access Journals
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