Daytime sleepiness predicts inflammation and ambulatory blood pressure in sleep apnoea
| Autor: | Victoria M. Pak, Brittany Butts, Vicki Hertzberg, Nancy Collop, Arshed A. Quyyumi, John Cox, Ann Rogers, Sandra B. Dunbar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 6, Iss 4 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00310-2019 |
| Popis: | Introduction Sleepiness in obstructive sleep apnoea is associated with cardiovascular risk; however, the biological mechanisms are not known. This study explored whether those with subjective sleepiness have increased plasma tumour necrosis factor-related protein 1 (C1qTNF1), a novel adipose-derived hormone (adipokine), and 24-h ambulatory blood pressure (ABP) compared to those without sleepiness in newly diagnosed, treatment-naïve participants with obstructive sleep apnoea. Methods Overall, 94 participants were included in the analysis. Participants completed the Epworth Sleepiness Scale (ESS), 24-h ABP was monitored, and plasma C1qTNF1 was measured. Sleepy participants were defined as ESS≥10 and nonsleepy as ESS |
| Databáze: | Directory of Open Access Journals |
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