Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism

Autor: Nana L. Christensen MLS, Steen Jakobsen PhD, Anna C. Schacht PhD, Ole L. Munk PhD, Aage K. O. Alstrup DVM, PhD, Lars P. Tolbod PhD, Hendrik J. Harms PhD, Søren Nielsen MD, PhD, Lars C. Gormsen MD, PhD
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Molecular Imaging, Vol 16 (2017)
Druh dokumentu: article
ISSN: 1536-0121
15360121
DOI: 10.1177/1536012117734485
Popis: Introduction: Despite the decades long use of [ 11 C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published. Methods: Dosimetry and biodistribution studies were performed in 2 pigs and 2 healthy volunteers by whole-body [ 11 C]palmitate PET scans. Metabolite studies were performed in 40 participants (healthy and with type 2 diabetes) under basal and hyperinsulinemic conditions. Metabolites were estimated using 2 approaches and subsequently compared: Indirect [ 11 C]CO 2 release and parent [ 11 C]palmitate measured by a solid-phase extraction (SPE) method. Finally, myocardial fatty acid uptake was calculated in a patient cohort using input functions derived from individual metabolite correction compared with population-based metabolite correction. Results: In humans, mean effective dose was 3.23 (0.02) µSv/MBq, with the liver and myocardium receiving the highest absorbed doses. Metabolite correction using only [ 11 C]CO 2 estimates underestimated the fraction of metabolites in studies lasting more than 20 minutes. Population-based metabolite correction showed excellent correlation with individual metabolite correction in the cardiac PET validation cohort. Conclusion: First, mean effective dose of [ 11 C]palmitate is 3.23 (0.02) µSv/MBq in humans allowing multiple scans using ∼300 MBq [ 11 C]palmitate, and secondly, population-based metabolite correction compares well with individual correction.
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