The Urotensin II System And Carotid Atherosclerosis: A Role In Vascular Calcification

Autor: Isabella eAlbanese, Stella S Daskalopoulou, Bin eYu, Zhipeng eYou, Jacques eGenest, Alawi eAlsheikh-Ali, Adel Giaid Schwertani
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Frontiers in Pharmacology, Vol 7 (2016)
Druh dokumentu: article
ISSN: 1663-9812
DOI: 10.3389/fphar.2016.00149
Popis: Background and aims: The aims of the present study were to determine the expression of urotensin II (UII), urotensin-II related peptide (URP) and their receptor (UT) in stable and unstable carotid atherosclerosis, and determine the effects of UII on human aortic smooth muscle cell (SMCs) calcification.Methods and Results: We examined UII, URP and UT protein expression in 88 carotid endarterectomy specimens using immunohistochemistry. Expression of UII, URP and UT was more evident in unstable compared to stable plaques (P
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