| Autor: |
S Kalogerakou, E Tsaltas, E Anyfandi, VM Papakosta, D Kontis, E Angelopoulos, CC Papageorgiou, IM Zervas, Oulis |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Dialogues in Clinical Neuroscience & Mental Health, Vol 1, Iss s1 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2585-2795 |
| DOI: |
10.26386/obrela.v1i0.16 |
| Popis: |
The findings from a series of studies on patients with damage to the prefrontal cortex, as well as experiments with functional neuroimaging on normal subjects, have highlighted the specialized role of the ventral part of the lateral prefrontal cortex BACKGROUND: Pharmacoresistant patients with major depression (MDD) and electroconvulsive therapy referral (ECT) may present distinct neuropsychological profiles from drug-respondent patients. Such differences could help identify MDD subtypes, offering insights into the mechanisms underlying differential treatment response. The sensitivity of distinct neuropsychological deficits to clinically effective ECT could extend such insights. METHOD: Depressed patients with (1) ECT referral (ECTs), (2) no ECT referral (NECTs) and (3) controls (matched groups, n=15) were assessed with Hamilton Depression, Hamilton Anxiety and Mini-Mental State Examination scales and five memory and executive function tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). ECT candidates were reassessed at the end of ECT (post-ECT) and 2 months thereafter (follow-up). RESULTS: ECTs scored significantly lower than NECTs in the MMSE (p=0.01). NECTs performed worse than Controls in Paired Associates Learning (PAL) task (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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