wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia

Autor: Helmut Piazena, Werner Müller, Peter Vaupel
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Hyperthermia, Vol 37, Iss 1, Pp 887-896 (2020)
Druh dokumentu: article
ISSN: 0265-6736
1464-5157
02656736
DOI: 10.1080/02656736.2020.1792562
Popis: Purpose The quality assurance guidelines of the European Society for Hyperthermic Oncology (ESHO) specify the requirements for appropriate superficial heating using phantoms. In this current piglet study, we have examined these requirements under in vivo conditions. Materials and Methods The evaluation is based on simultaneous, invasive temperature measurements at 8 different depths between 2 and 20 mm in the thigh of anesthetized piglets during irradiation with water-filtered infrared radiation (wIRA). Temperature probes were equally distributed in an area of 10 cm diameter of homogeneously irradiated skin. Piglets were irradiated to 126.5 mW cm−2 in the spectral range of IR-A. Results Heating rates and specific absorption rates were in full accordance with the ESHO standards. Due to early onset of thermoregulation, the desired temperature rise of 6 K at a depth of 5 mm was achieved after about 10 min of exposure, i.e. 4 min later than required for phantoms. After reaching thermal steady state, on average T90 ≥ 40 °C occurred in tissue depths up to 20 mm, T50 ≥ 41 °C up to 16 mm, and a mean CEM43T90 ≈ 1 min was calculated for depths up to 8 mm. Conclusions Piglet data are comparable with preliminary literature data assessed in vivo in the abdominal wall and in recurrent breast cancer of humans. The potential of wIRA-HT for adequate treatment of superficial tissues/cancers in the clinical setting thus is confirmed. To ensure therapeutically needed doses of wIRA-HT, irradiation times should be extended.
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