Research on the Improvement Effects of Collagen Peptides and Tremella fuciformis Polysaccharides on the Skin Texture of Aging Mice and Its Mechanism

Autor: Xiaofei XU, Xingwei ZHONG, Mingyue ZHAO, Ruiqi HE
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Shipin gongye ke-ji, Vol 43, Iss 8, Pp 357-364 (2022)
Druh dokumentu: article
ISSN: 1002-0306
DOI: 10.13386/j.issn1002-0306.2021060067
Popis: Objective: To compare the improvement effects of collagen peptides and Tremella fuciformis polysaccharides (TFP) on aging skin texture and explore the underlying mechanism of the action. Method: Aging mice models were established by intraperitoneal injection of D-galactose at a dosage of 120 mg/kg, which were randomly divided into three groups: Model (given saline), collagen (given collagen peptides 830 mg/kg·BW), and TFP (given TFP 100 mg/kg·BW). Adult mice were set as normal group (Normal). The experiments lasted for 8 weeks. All mice were killed at the end of the experiment. The contents of hydroxyproline and hyaluronic acid in the skin, the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) in several tissues, the levels of inflammatory cytokines in serum, and the concentrations of intestinal short chain fatty acids (SCFAs) were measured. Results: Collagen peptides and TFP significantly increased the contents of hydroxyproline and hyaluronic acid in aging skin in mice (P
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