| Autor: |
T. HUSSAIN, I. JAVED, F. H. KHAN, F. MUHAMMAD, B. ASLAM, S. AHMAD1, I. U. JAN2, A. BASIT AND U. TAHIR |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Pakistan Veterinary Journal, Vol 29, Iss 3, Pp 121-124 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
0253-8318 |
| Popis: |
Effect of paracetamol on renal clearance and urinary excretion of isoniazid was investigated in eight healthy adult female goats in two phases. In the first phase, each goat was administered isoniazid orally as a single dose at the rate of 10 mg/kg body weight. A washout period of 7 days was given before the second phase in which the same dose of isoniazid was administered along with paracetamol orally at the dose rate of 15 mg /kg. In both phases, blood and urine samples were collected at various time intervals post drug administration and analyzed for isoniazid and creatinine concentrations. The value of diuresis after single administration of isoniazid was 0.084 ± 0.0056 ml/min.kg, while following concurrent administration with paracetamol it decreased to 0.058 ± 0.0067 ml/min.kg (P>0.05). Mean values for renal clearance of creatinine following single and concurrent administration of isoniazid with paracetamol were 2.52 ± 1.151 and 1.82 ± 0.098 ml/min.kg, respectively, while respective values for renal clearance of isoniazid were 1.67 ± 0.116 and 0.80 ± 0.021 ml/min.kg (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
