| Autor: |
李爱媛1，范萍1，李现军2，赵喆1，战同霞3，谢海1 (LI Aiyuan1, FAN Ping1, LI Xianjun2, ZHAO Zhe1, ZHAN Tongxia3, XIE Hai1 ) |
| Jazyk: |
čínština |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Zhongguo cuzhong zazhi, Vol 19, Iss 2, Pp 150-157 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1673-5765 |
| DOI: |
10.3969/j.issn.1673-5765.2024.02.005 |
| Popis: |
目的 探讨18氟代脱氧葡萄糖（18F-fluorodeoxyglucose，18F-FDG）PET/CT预测活动性恶性肿瘤（active cancer，AC）患者发生急性缺血性卒中（acute ischemic stroke，AIS）的标志物指标。 方法 回顾性纳入2021年1月—2022年5月于潍坊医学院第一附属医院行18F-FDG PET/CT检查的AC住院患者，根据其检查后1年内是否发生AIS分为AIS组和非AIS组，通过患者基本特征（性别、年龄、体重、恶性肿瘤部位、PET/CT检查前空腹血糖）进行1∶1倾向评分匹配，分析两组患者的临床及18F-FDG PET/CT影像学资料差异。影像学资料主要有颈动脉（carotid artery，CA）、升主动脉和主动脉弓（ascending aorta and aortic arch，AAO-AOA）、降主动脉（descending aorta，DAO）、髂动脉和股动脉（iliac artery and femoral artery，IA-FA）、内脏脂肪组织（visceral adipose tissue，VAT）、皮下脂肪组织（subcutaneous adipose tissue，SAT）以及全肠道（total bowel，TB）的靶本底比（target to background ratio，TBR），VAT和SAT面积以及两者比值。对单因素logistic回归中P＜0.1的变量采用逐步向后logistic回归筛选AC患者发生AIS的独立危险因素，应用ROC曲线评估独立危险因素联合模型对AIS的预测价值。 结果 共纳入88例患者，平均年龄（69.8±8.8）岁，男性占72.7%（64例），AIS组和非AIS组各 44例。AIS组合并冠心病比例较非AIS组高，CA、AAO-AOA、DAO、IA-FA、VAT、SAT以及TB的TBR均较非AIS组增高，而VAT面积较AIS组低，差异均有统计学意义。多因素logistic回归显示，冠心病（OR 3.92，95%CI 1.11～13.87，P=0.034）、CA TBR≥1.80（OR 2.90，95%CI 1.04～8.10，P=0.042）、DAO TBR≥2.30（OR 4.13，95%CI 1.45～11.75，P=0.008）、TB TBR≥3.34（OR 2.87，95%CI 1.01～8.12，P=0.047）和VAT TBR≥0.44（OR 3.92，95%CI 1.39～11.09，P=0.010）是AC患者发生AIS的独立危险因素，联合上述5个指标绘制ROC的AUC为0.821（95%CI 0.736～0.906，P＜0.001），预测肿瘤患者发生AIS的敏感度为68.2%，特异度为81.8%。 结论 有冠心病史，CA、DAO、VAT和TB的TBR增高是AC患者发生AIS的独立危险因素，上述5个指标联合对AC患者AIS的发生具有一定的预测价值。 Abstract: Objective To explore which indicators of 18F-fluorodeoxyglucose (18F-FDG) PET/CT imaging can be used as markers for predicting acute ischemic stroke (AIS) in active cancer (AC) patients. Methods Inpatients with AC who underwent 18F-FDG PET/CT in the First Affiliated Hospital of Weifang Medical University from January 2021 to May 2022 were retrospectively included, and divided into AIS group and non-AIS group according to whether they developed AIS within 1 year after the examination. According to the basic characteristics of the patients (gender, age, weight, cancer site, fasting blood glucose before PET/CT examination) by 1∶1 propensity score matching, clinical and 18F-FDG PET/CT imaging data of both groups of patients were analyzed, mainly including the target to background ratios (TBRs) of carotid arteries (CA), ascending aorta and aortic arch (AAO-AOA), descending aorta (DAO), iliac artery and femoral artery (IA-FA), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total bowel (TB), the area of VAT and SAT and the ratio between the two. For variables with P |
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