The impact of MEIS1 TALE homeodomain transcription factor knockdown on glioma stem cell growth

Autor: Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animal Cells and Systems, Vol 28, Iss 1, Pp 93-109 (2024)
Druh dokumentu: article
ISSN: 19768354
2151-2485
1976-8354
37671820
DOI: 10.1080/19768354.2024.2327340
Popis: Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that MEIS1 is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of MEIS1 expression by shRNA significantly reduced GSC growth in both in vitro and in vivo experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that MEIS1 expression is correlated to cell cycle-related genes. Clinical data analysis revealed that MEIS1 expression is elevated in high-grade gliomas, and patients with high MEIS1 levels have poorer overall survival outcomes. The findings suggest that MEIS1 is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.
Databáze: Directory of Open Access Journals
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