Acute Toxicity of Total Body Irradiation Using Volumetric Arc Therapy With a Focus on the Effect of Lung Dose Rate

Autor: Michael Kole Melton, MD, Dennis N. Stanley, PhD, Zohaib Iqbal, PhD, Kimberly S. Keene, MD, Eric Simiele, PhD, DABR, Andrew McDonald, MD, MS
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Advances in Radiation Oncology, Vol 9, Iss 4, Pp 101430- (2024)
Druh dokumentu: article
ISSN: 2452-1094
DOI: 10.1016/j.adro.2023.101430
Popis: Purpose: To report adverse effects of high dose total body irradiation (TBI) delivered using a volumetric arc therapy (VMAT) technique and to assess pulmonary toxicity at dose rates of 40 and 100 monitor units per minute (MU/min). Methods and Materials: This retrospective study included patients >18 years old who received ≥8 Gy TBI using a VMAT technique. The TBI dose was prescribed to a planning target volume consisting of a 0.5 cm retraction of the body with the lungs subtracted. The objective function specified planning target volume coverage goals of D100% ≥ 90% and Dmax
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