The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

Autor:	Rongxian An, Qian Luo, Lei Li, Dinglu Cui, Jingchun Jin
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Primary osteoporosis Resveratrol Animal models Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Zdroj:	Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-14 (2024)
Druh dokumentu:	article
ISSN:	1749-799X
DOI:	10.1186/s13018-024-04595-1
Popis:	Abstract Background There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. Methods The PubMed, Cochrane Library, Web of Science and Embase databases were searched up to August 2023. The risk of bias was assessed by the SYRCLE RoB tool. Random- or fixed-effects models were used to determine the 90% confidence interval (CI) or standardized mean difference (SMD). Statistical analysis was performed with RevMan 5.4 and Stata 14.0. Results A total of 24 studies containing 714 individuals were included. Compared with those in the control group, the bone mineral density (BMD) (P
Databáze:	Directory of Open Access Journals
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