Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption.

Autor: Needa A Virani, Olivia J Kelada, Sijumon Kunjachan, Alexandre Detappe, Jihun Kwon, Jennifer Hayashi, Ana Vazquez-Pagan, Douglas E Biancur, Thomas Ireland, Rajiv Kumar, Srinivas Sridhar, G Mike Makrigiorgos, Ross I Berbeco
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS ONE, Vol 15, Iss 7, p e0236245 (2020)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0236245
Popis: We have previously demonstrated that endothelial targeting of gold nanoparticles followed by external beam irradiation can cause specific tumor vascular disruption in mouse models of cancer. The induced vascular damage may lead to changes in tumor physiology, including tumor hypoxia, thereby compromising future therapeutic interventions. In this study, we investigate the dynamic changes in tumor hypoxia mediated by targeted gold nanoparticles and clinical radiation therapy (RT). By using noninvasive whole-body fluorescence imaging, tumor hypoxia was measured at baseline, on day 2 and day 13, post-tumor vascular disruption. A 2.5-fold increase (P
Databáze: Directory of Open Access Journals
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