| Autor: |
Trond Ø. Jørgensen, Jeanette H. Andersen, Kinga Leszczak, Magnus Engqvist, Bjarne Østerud, Karl-Erik Eilertsen, Annette Bayer, Espen Hansen, Karianne F. Lind |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 11, Iss 7, Pp 2655-2666 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md11072655 |
| Popis: |
In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activity. Barettin was also able to inhibit the secretion of the inflammatory cytokines IL-1β and TNFα from LPS-stimulated THP-1 cells. This combination of anti-inflammatory and antioxidant activities could indicate that barettin has an atheroprotective effect and may therefore be an interesting product to prevent development of atherosclerosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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