Hats off to 20S proteasome substrate discovery

Autor: Taylor R Church, Anna Brennan, Seth S Margolis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Molecular Systems Biology, Vol 20, Iss 4, Pp 293-295 (2024)
Druh dokumentu: article
ISSN: 1744-4292
DOI: 10.1038/s44320-024-00028-7
Popis: Uncapped free 20S proteasomes are abundant and active in cells, and yet their degraded intracellular protein substrates have remained underexplored. In their recent study, Sharon and colleagues (Pepelnjak et al, 2024) developed an advanced proteomics method (PiP-MS) to comprehensively explore 20S proteasome substrates in the human proteome.
Databáze: Directory of Open Access Journals
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