Antinociceptive Effects of Paeonia daurica subsp. macrophylla Root Extracts in Mice
| Autor: | Hamidreza Monsef-Esfahani, Sahand Jamshidi, Paria Sharafi-Badr, Mohammad Sharifzadeh, Mahdi Vazirian, Seyede Nargess Sadati Lamardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Traditional and Integrative Medicine, Vol 8, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2476-5104 2476-5112 |
| DOI: | 10.18502/tim.v8i1.12398 |
| Popis: | This study aimed to assess the antinociceptive activity of extracts and fractions of Paeonia daurica subsp. macrophylla in BALB/c mice. Various doses of hydro-alcoholic extract (HE), hexane fraction (F-hexane), methanol (F-MeOH), and chloroform (F-CHCl3), as well as aqueous extracts (AE), were evaluated by a well-known model, a formalin-induced pain test in mice. All extracts, piroxicam 0.1 mg/kg, and negative control groups were administered 30 minutes before formalin injection. Flinching, licking, and biting reflexes were measured as painful factors compared with controls at intervals of 0 to 5 minutes, 0 to 15, and 0 to 60 minutes after formalin injection. The acute oral toxicity test of total ethanolic and aqueous extracts showed no signs of toxic effect up to a dose of 5000 mg/kg. In the formalin test at a time interval of 0 to 5 minutes, there was no significant difference between the results of the study groups. In the range of 0 to 15 minutes, the effect of AE (1 g/kg), HE (2, 3 g/kg), and F-hexane (1 g/kg) was significantly higher than the positive control group (p |
| Databáze: | Directory of Open Access Journals |
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