Serum myeloperoxidase chlorinating activity in acute ischemic stroke
| Autor: | Mirić M., Dragojević I., Kisić B., Biševac B., Filipović S., Marjanović J., Dejanović M. |
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| Jazyk: | English<br />Serbian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Praxis Medica, Vol 44, Iss 1, Pp 1-6 (2015) |
| Druh dokumentu: | article |
| ISSN: | 0350-8773 22657614 |
| DOI: | 10.5937/pramed1501001M |
| Popis: | Beyond traditional risk factors, inflammation is believed to play a role in the development of ischemic stroke (IS). During inflammation neutrophil leukocytes degranulate, thereby releasing the enzyme myeloperoxidase (MPO) into extracellular space. In addition to peroxidase activity, MPO expresses also a chlorinating activity, and catalyzes the formation of hypochlorous acid and long-lived oxidants - chloramines. In this study we assessed serum chlorinating MPO activity and concentration of total chloramines. We included 29 patients with acute IS, aged 69.0 years (64.2 - 78.0) and 25 control subjects without IS, aged 69.0 years (67.0 - 72.0). It was found that neutrophil cell count was higher in IS than in controls (4.56 ± 1.76 vs. 7.74 ± 3.35 × 109/L, in control and IS group, respectively; p< 0.05). Serum chlorinating MPO activity was also higher in IS group than in controls (67.2 U/L vs. 92.3 U/L, in controls and in patients, respectively; p < 0.05). Concentration of total chloramines was higher in IS group than in controls, but the difference did not reach statistical significance (p=0.178). MPO activity was significantly correlated with serum triglycerides (p |
| Databáze: | Directory of Open Access Journals |
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