Oral biopsy in mucous membrane pemphigoid and pemphigus vulgaris with gingival expression: the optimal site. A systematic review and meta-analysis

Autor: Sophie-Myriam Dridi, Claire Manon Lutz, Frédérick Gaultier, Fadel Bellakhdar, Sébastien Jungo, Anne Laure Ejeil
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Oral Health, Vol 24, Iss 1, Pp 1-27 (2024)
Druh dokumentu: article
ISSN: 1472-6831
DOI: 10.1186/s12903-024-04853-y
Popis: Abstract Purpose In order to diagnose mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV) with gingival expression, clinical data must be compared with immunohistochemical data obtained using direct immunofluorescence (DIF). It is therefore essential to carry out a good quality mucosal biopsy for this vital additional test. To date, no study has been able to effectively guide clinicians in their choice of oral site for biopsy to guarantee the efficient contribution of DIF to diagnosis. We propose a systematic review of the literature and a meta-analysis to clarify this issue. Materials and Methods Electronic databases and bibliographies of articles were searched in April 2023. The primary outcome was the rate of DIF + contribution to diagnosis according to the location of the oral site biopsied. Results 16 studies were included. Gingival biopsies showed a rate of DIF + 100% [97%-100%] p = 0.998 I2 = 0.0% with no heterogeneity for PV, and 90.2% [66.5%-100%] p
Databáze: Directory of Open Access Journals