| Autor: |
Mulik Alexander, Novochadov Valery, Bondarev Alexander, Lipnitskaya Sofya, Ulesikova Irina, Shatyr Yulia |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of Integrative Bioinformatics, Vol 13, Iss 4, Pp 33-42 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1613-4516 |
| DOI: |
10.1515/jib-2016-295 |
| Popis: |
The objective of the study was to investigate the genetic basis of general non-specific reactivity of an organism. Systematic search in PubMedCentral, PDB, KEGG and SNP databases identified a set of genes and their polymorphisms that can determine pain sensitivity and therefore the level of general non-specific reactivity of the human organism. Six SNPs were selected for genotyping kit design; 230 healthy volunteers were enrolled in the study. It was revealed that very high pain threshold was associated with allele A in rs1851048 and allele C in rs6777055. High level of general non-specific reactivity of an organism was associated with allele G in rs2562456 (OR=1.804, CI=1.139-2.857, p=0.011) and allele C in rs6923492 (OR=1.582, CI=1.071-2.335, p=0.021). Low level of general non-specific reactivity of an organism was associated with allele T in rs6923492 (OR=0.351, CI=0.154-0.799, p=0.010). A set of genes and single-nucleotide polymorphisms associated with the pain sensitivity and indirectly with the level of general non-specific reactivity of human organism were determined. The identified correlations reveal some molecular mechanisms of general non-specific reactivity of an organism variability and can guide further research in this area. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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