Successful administration of recombinant human antithrombin in a pregnant Japanese woman with hereditary antithrombin deficiency

Autor: Yuya Fujibe, Tasuku Mariya, Masahito Mizuuchi, Shinichi Ishioka, Masahiro Yoshida, Tsuyoshi Saito
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Taiwanese Journal of Obstetrics & Gynecology, Vol 58, Iss 6, Pp 849-851 (2019)
Druh dokumentu: article
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2019.09.021
Popis: Objective: Hereditary antithrombin (AT) deficiency increases the risk of venous thromboembolism (VTE) in pregnant woman. We report the first case of administration of recombinant human antithrombin (rhAT) to a pregnant Japanese woman with AT deficiency. Case report: A 30-year-old woman, gravida 2 para 0, was referred to our hospital because of AT deficiency. Unfractionated heparin was administered from 13 weeks of gestation and rhAT was administered from labor onset. A cesarean section was performed and the patient and her baby were healthy, with no sequelae. Conclusion: We concluded that rhAT was effective for preventing VTE during delivery, with no potential infection risks. Keywords: Hereditary antithrombin deficiency, Pregnancy, Prophylaxis, Recombinant human antithrombin, Venous thromboembolism
Databáze: Directory of Open Access Journals