The Impact of Recombinant Human Erythropoietin Administration in Critically ill COVID-19 Patients: A Multicenter Cohort Study

Autor: Khalid Al Sulaiman BCCCP, BCNSP, MBA, FCCM, Ohoud Aljuhani Pharm.D, BCCCP, Ghazwa B. Korayem Pharm.D, Ali F. Altebainawi Pharm.D, Ramesh Vishwakarma PhD, Mashael AlFaifi Pharm.D, Samiah Alsohimi Pharm.D, Aljoharah Alrayes Pharm.D, Sara Albishi Pharm.D, Reem Alqahtani Pharm.D, Mai Alalawi Pharm.D, Ibrahim Al Sulaihim MSc, Thamer A. Alanazi BSc, Rahaf A. Alqahtani Pharm.D, Alaa Almagthali Pharm.D, Shahamah Jomah BSc, Areej Alshlowi BSc, Tahani R. Alshammari BSc, Shahad S. Alzahrani Pharm.D, Marwa I. Abdulqader Pharm.D
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023)
Druh dokumentu: article
ISSN: 1938-2723
10760296
DOI: 10.1177/10760296231218216
Popis: The use of erythropoietin-stimulating agents (ESAs) as adjunctive therapy in critically ill patients with COVID-19 may have a potential benefit. This study aims to evaluate the effect of ESAs on the clinical outcomes of critically ill COVID-19 patients. A multicenter, retrospective cohort study was conducted from 01-03-2020 to 31-07-2021. We included adult patients who were ≥ 18 years old with a confirmed diagnosis of COVID-19 infection and admitted to intensive care units (ICUs). Patients were categorized depending on ESAs administration during their ICU stay. The primary endpoint was the length of stay; other endpoints were considered secondary. After propensity score matching (1:3), the overall included patients were 120. Among those, 30 patients received ESAs. A longer duration of ICU and hospital stay was observed in the ESA group (beta coefficient: 0.64; 95% CI: 0.31-0.97; P = < .01, beta coefficient: 0.41; 95% CI: 0.12-0.69; P = < .01, respectively). In addition, the ESA group's ventilator-free days (VFDs) were significantly shorter than the control group. Moreover, patients who received ESAs have higher odds of liver injury and infections during ICU stay than the control group. The use of ESAs in COVID-19 critically ill patients was associated with longer hospital and ICU stays, with no survival benefits but linked with lower VFDs.
Databáze: Directory of Open Access Journals
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