| Autor: |
Başak KAYHAN, Üner KAYABAŞ, Servet KÖLGELİER, Barış OTLU, Mehmet GÜL, Elçin Latife KURTOĞLU, Yaşar BAYINDIR |
| Jazyk: |
turečtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 5 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2147-673X |
| DOI: |
10.4274/mjima.2016.2 |
| Popis: |
Introduction: Brucella spp. are intracellular bacteria that may cause acute, subacute and chronic infections. Despite optimum antibiotic treatment, relapse of brucellosis occurs in some patients. There is less amount of knowledge about immune response in relapse of brucellosis. Materials and Methods: Twenty patients with acute brucellosis, 16 patients with relapsed brucellosis and as a control group 20 healthy volunteers were enrolled in this study to explore the immune response variation during relapse of brucellosis. The distribution of peripheral blood mononuclear cells was investigated by flow cytometry and level of various cytokines involved in inflammatory and anti-inflammatory response were measured by enzyme-linked immunosorbent assay in serum samples. Results: The most prominent data in phenotyping examination was the significant reduction (1.45 times) in the percentage of activated T cell (CD3+human leukocyte antigen-DR+) population in the relapse group in comparison to the acute brucellosis group. However, percentage of activated T cell population in the relapse group was 2.59 times higher than in healthy controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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