Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
| Autor: | Laura Chiecchio, Gian Paolo Dagrada, Rebecca K.M. Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C.P. Cross, Christine J. Harrison, Fiona M. Ross |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 94, Iss 7 (2009) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.2008.004440 |
| Popis: | We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells ( |
| Databáze: | Directory of Open Access Journals |
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