| Autor: |
Lejing Zang, Renqian Feng, Yitong Huang, Jiahe Huang, Yan Hu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Oncology, Vol 13 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2023.1306376 |
| Popis: |
ObjectiveThe female reproductive tract is a significant microecological region, and its micro-environment can directly affect women’s cervical health. This research aimed to investigate the effect of vaginal microecology on human papillomavirus (HPV) infection and cervical intraepithelial neoplasia(CIN).MethodsA retrospective cohort study enrolling 2,147 women who underwent a colposcopic examination between August 2021 and August 2022 was conducted. The relationship between vaginal microecology and HPV infection as well as cervical lesions were assessed using the chi-square test, univariate and multivariate logistic regression analyses, and Cochran-Armitage trend test.ResultsHPV infection was linked to the imbalance of vaginal microecology [odds ratio (OR)=3.00, 95% confidence interval (CI)=1.66–5.43; P 0.05), the proportions of abnormal PH value (OR=2.6, 95% CI=1.63–10.42; P=0.001) and abnormal vaginal cleanliness (OR=2.6, 95% CI=1.36–4.0; P= 0.004) increased as the histological stage progressed.ConclusionVaginal microecology associates with HPV infection and the progression of cervical lesions. Detection of vaginal secretion may contribute to the development of targets for micro-environmental modulation with probiotics and the reduction of the incidence of cervical cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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