Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?

Autor:	Wenhao Luo, Gang Yang, Jiangdong Qiu, Jingyang Luan, Ying Zhang, Lei You, Mengyu Feng, Fangyu Zhao, Yueze Liu, Zhe Cao, Lianfang Zheng, Taiping Zhang, Yupei Zhao
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	chemistry drug therapy metabolism pancreatic cancer prevention Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 8, Iss 14, Pp 6403-6413 (2019)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.2384
Popis:	Abstract Pancreatic cancer (PC) remains one of the deadliest malignancies worldwide. Chemoresistance is a significant clinical problem in pancreatic ductal adenocarcinoma (PDAC) and numerous potential mechanisms have been demonstrated but much remains to be understood. To overcome the existing limitations in PC treatment, newer approaches targeting intrinsic or acquired mechanisms have been found to improve drug therapeutic effectiveness in PC patients. Here, we provide an update of the most recent findings and their implications for clinicians, and attempt to summarize the various aspects of different individualized novel therapies for PC that could most benefit metastatic PDAC patients.
Databáze:	Directory of Open Access Journals
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