| Autor: |
Farmiza Begum, Pooja J Kotian, Snigdha Hiremath, Atharva Ramdasi, Apoorva Sharma, Fathima Beegum, Prasada Chowdhari Gurram, Madhavan Nampoothiri, Nandakumar Krishnadas, Rekha R Shenoy |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Pharmaceutical Sciences, Vol 30, Iss 3, Pp 332-338 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2383-2886 |
| DOI: |
10.34172/PS.2024.8 |
| Popis: |
Background: Wound healing is a complex, multifactorial process in which poor healing in chronic wounds has emerged as the most significant complication in recent years. Jojoba oil (JO) has been traditionally used for its medicinal properties, especially for skin disorders. Studies suggested its potential wound-healing activity in-vitro. However, the underlying mechanism by which JO promotes the rejuvenating process is unclear in-vivo. The present study was aimed at evaluating the wound-healing activity of JO in both normal and delayed healing. Methods: Excision wounds were inflicted by surgical method on the anesthetized rats. Animal wounds were explored for their healing activity by photography in-vivo. Expression of ERK, collagen, VEGF and PDGF was investigated using western blot. Results: Topical administration of JO (0.5 ml/wound, twice a day) showed significant wound healing activity. All groups demonstrated a significant increase (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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