| Autor: |
Gathsaurie Neelika Malavige, Louise Jones, S D Kamaladasa, A Wijewickrama, S L Seneviratne, Antony P Black, Graham S Ogg |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 3, Iss 11, p e3789 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0003789 |
| Popis: |
BACKGROUND:In Sri Lanka, varicella zoster virus (VZV) is typically acquired during adulthood with significant associated disease morbidity and mortality. T cells are believed to be important in the control of VZV replication and in the prevention of reactivation. The relationship between viral load, disease severity and cellular immune responses in primary VZV infection has not been well studied. METHODOLOGY:We used IFNgamma ELISpot assays and MHC class II tetramers based on VZV gE and IE63 epitopes, together with quantitative real time PCR assays to compare the frequency and phenotype of specific T cells with virological and clinical outcomes in 34 adult Sri Lankan individuals with primary VZV infection. PRINCIPAL FINDINGS:Viral loads were found to be significantly higher in patients with moderate to severe infection compared to those with mild infection (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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