Preferences of patients and health professionals for route and frequency of administration of biologic agents in the treatment of rheumatoid arthritis

Autor: Huynh TK, Østergaard A, Egsmose C, Madsen OR
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Patient Preference and Adherence, Vol 2014, Iss default, Pp 93-99 (2014)
Druh dokumentu: article
ISSN: 1177-889X
Popis: Tuan Khai Huynh,1,2 Ann Østergaard,3 Charlotte Egsmose,3 Ole Rintek Madsen31Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Frederiksberg, Denmark; 2Department of Rheumatology, Copenhagen University Hospital Hillerød, Hillerød, Denmark; 3Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup, DenmarkObjectives: To examine the preferences of rheumatoid arthritis (RA) patients and health professionals (HPs) for the route and frequency of administration of biologic drugs.Methods: One hundred and seven RA patients treated with biological agents for intravenous or subcutaneous use, 35 biologic-naïve RA patients treated with a disease-modifying antirheumatic drug and 30 rheumatology HPs (physicians and nurses) were recruited from two outpatient clinics in Copenhagen, Denmark. All subjects filled out a questionnaire interrogating their choice of preferred route and frequency of administration of a biologic corresponding to current available options, given that effects, adverse effects, and financial costs were identical for the different choices. The subjects were also asked to justify their preferences. The chi-square goodness-of-fit test was used to examine the distributions over different preferences. Proportions were compared using Fisher's exact test.Results: Forty-one patients were currently treated with subcutaneous self-injections at home (SCH) and 66 intravenously at the clinic (IVC). IVC was preferred by 85% of patients currently treated with IVC (P
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