Stabilization of Tuberculosis Reporter Enzyme Fluorescence (REFtb) Diagnostic Reagents for Use at the Point of Care

Autor:	Maxim Lebedev, Aaron B. Benjamin, Kent J. Koster, Kathryn E. Broyles, Sathish Kumar, Joseph M. Jilka, Jeffrey D. Cirillo
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	tuberculosis diagnostics beta lactamase BlaC lactose mannitol Medicine (General) R5-920
Zdroj:	Diagnostics, Vol 12, Iss 7, p 1745 (2022)
Druh dokumentu:	article
ISSN:	2075-4418
DOI:	10.3390/diagnostics12071745
Popis:	Tuberculosis is one of the most frequent causes of death in humans worldwide. One of the primary reasons tuberculosis remains a public health threat is that diagnosis can take weeks to months, is often not very sensitive and cannot be accomplished in many remote environments. A rapid, sensitive and inexpensive point-of-care (POC) diagnostic would have a major impact on tuberculosis eradication efforts. The tuberculosis diagnostic system REFtb is based on specific detection of the constitutively expressed β-lactamase (BlaC) in Mycobacterium tuberculosis using a custom fluorogenic substrate designated as CDG-3. REFtb has potential as a diagnostic for tuberculosis that could be very inexpensive (
Databáze:	Directory of Open Access Journals
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