| Autor: |
Kiyohisa Kamimura, Yoshiki Kamimura, Tsubasa Nakano, Tomohito Hasegawa, Masanori Nakajo, Chihiro Yamada, Kentaro Akune, Fumitaka Ejima, Takuro Ayukawa, Soichiro Ito, Hiroaki Nagano, Koji Takumi, Masatoyo Nakajo, Hiroyuki Uchida, Kazuhiro Tabata, Takashi Iwanaga, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Cancer Imaging, Vol 23, Iss 1, Pp 1-13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1470-7330 |
| DOI: |
10.1186/s40644-023-00595-2 |
| Popis: |
Abstract Background This study was designed to investigate the use of time-dependent diffusion magnetic resonance imaging (MRI) parameters in distinguishing between glioblastomas and brain metastases. Methods A retrospective study was conducted involving 65 patients with glioblastomas and 27 patients with metastases using a diffusion-weighted imaging sequence with oscillating gradient spin-echo (OGSE, 50 Hz) and a conventional pulsed gradient spin-echo (PGSE, 0 Hz) sequence. In addition to apparent diffusion coefficient (ADC) maps from two sequences (ADC50Hz and ADC0Hz), we generated maps of the ADC change (cADC): ADC50Hz − ADC0Hz and the relative ADC change (rcADC): (ADC50Hz − ADC0Hz)/ ADC0Hz × 100 (%). Results The mean and the fifth and 95th percentile values of each parameter in enhancing and peritumoral regions were compared between glioblastomas and metastases. The area under the receiver operating characteristic curve (AUC) values of the best discriminating indices were compared. In enhancing regions, none of the indices of ADC0Hz and ADC50Hz showed significant differences between metastases and glioblastomas. The mean cADC and rcADC values of metastases were significantly higher than those of glioblastomas (0.24 ± 0.12 × 10−3mm2/s vs. 0.14 ± 0.03 × 10−3mm2/s and 23.3 ± 9.4% vs. 14.0 ± 4.7%; all p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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