Correlation of BCL-2 and Ki-67 Expression with Clinicopathological Parameters in Oral Squamous Cell Carcinoma
| Autor: | S Ganraj Bhat, Sulata M Kamath, Vijaya V Mysorekar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 15, Iss 11, Pp XC07-XC11 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2021/51369.15702 |
| Popis: | Introduction: Oral Squamous Cell Carcinoma (OSCC) is the most common oral malignancy. Despite advancements in cancer therapeutics, early diagnosis, and prognosis of OSCC remains challenging. Evaluating clinicopathological characteristics, molecular biomarkers and their expression helps comprehend biological traits and tumour behaviour, which is crucial for early diagnosis and favourable prognosis. Aim: To evaluate the immunohistochemical expressions of B-cell Lymphoma 2 (BCL-2) and Ki-67 in OSCC and to correlate their molecular expressions with clinicopathological tumourigenic parameters. Materials and Methods: This cross-sectional study was conducted at Ramaiah Hospital, Bangalore, Karnataka, India, over a period of two years from June 2017 to May 2019 on 60 radical resection specimens of OSCC. After gross specimen examination, multiple representative tissue bits were obtained and subjected to Haematoxylin and Eosin (H&E) staining and staged. Immunohistochemical detection of BCL-2 and Ki-67 expression, semi-quantitative and intensity assessment of staining was performed. Data were analysed using statistical software R-version 4.0.1. The p≤0.05 was considered statistically significant. Results: The mean age was 57.88±13 years, and a large proportion were females (49, 81.67%). Mean BCL-2 and Ki-67 expression (%) were 24.58±11.29 and 29.5±17.21, respectively. The correlation of BCL-2 (p |
| Databáze: | Directory of Open Access Journals |
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