Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases
| Autor: | Hakan Korkmaz, Suzan Tabur, Esen Savaş, Mesut Özkaya, Nurten Aksoy, Şefika Nur Aksoy, Ersin Akarsu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Balkan Medical Journal, Vol 33, Iss 5, Pp 547-551 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2146-3123 2146-3131 |
| DOI: | 10.5152/balkanmedj.2016.15881 |
| Popis: | Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD) Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD. Study Design: Case control study. Methods: Fifty patients with AITD (25 Hashimoto’s thyroiditis (HT) and 25 Graves’ disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed. Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with –SH level in the patients with AITD. Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH. |
| Databáze: | Directory of Open Access Journals |
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