Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance

Autor: Yan-Ting Chen, Qi-Yuan Yang, Yun Hu, Xiang-Dong Liu, Jeanene M. de Avila, Mei-Jun Zhu, Peter W. Nathanielsz, Min Du
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27171-1
Popis: Maternal obesity predisposes offspring to obesity and metabolic disorders through incompletely understood mechanisms. Here the authors report that Dio3os is an imprinted long-coding RNA that modulates brown adipose tissue development and obesity resistance in the offspring.
Databáze: Directory of Open Access Journals