| Autor: |
Jo M Zelis, Frederik M Zimmermann, Froukje P J Andriessen, Patrick Houthuizen, Jop Van de Ven, Jolanda Leuverman, Nils P Johnson, Nico H J Pijls, Volkher Scharnhorst, Marcel Van 't Veer, Pim A L Tonino |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Open Heart, Vol 7, Iss 1 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2053-3624 |
| DOI: |
10.1136/openhrt-2019-001138 |
| Popis: |
BackgroundLoss of high-molecular-weight multimers (HMWMs) of von Willebrand factor (vWF) occurs due to high shear stress in patients with aortic stenosis. As symptoms of aortic stenosis occur during exercise, measurement of vWF during exercise might identify patients with aortic stenosis of clinical importance. The aim of this pilot study is to evaluate whether vWF changes over time as a result of exercise in patients with asymptomatic moderate or severe aortic stenosis.MethodsTen subjects were analysed for changes in vWF by measuring HMWMs and closure time with adenosine diphosphate (CT-ADP). All subjects underwent a full stress test on a bicycle ergometer. At rest and at peak exercise, a transthoracic echocardiogram was performed. HMWMs and CT-ADP were assessed at baseline, during and after exercise.ResultsHMWMs and CT-ADP did not change significantly during exercise, p=0.45 and p=0.65, respectively. HMWMs and CT-ADP correlated well, Spearman’s rho −0.621, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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