| Autor: |
N. V. Pervushin, G. S. Kopeina, B. Zhivotovsky |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biology Direct, Vol 18, Iss 1, Pp 1-7 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1745-6150 |
| DOI: |
10.1186/s13062-023-00431-4 |
| Popis: |
Abstract Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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