| Autor: |
Otto Mayer, Jan Filipovsky, Jitka Seidlerova, Petra Karnosova, Peter Wohlfahrt, Renata Cifkova, Jindra Windrichova, Ondrej Topolcan |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Artery Research, Vol 12 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2015.10.027 |
| Popis: |
It has been suggested that accumulation of advanced glycation end-products (AGE) is involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, prevents them from binding to the cell-surface receptor and protects against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness. In a cross-sectional design, we analyzed 1077 subjects from the Czech population-based study (“Post-MONICA”). Aortic pulse wave velocity (aPWV) was measured using a Sphygmocor device. sRAGE concentrations were assessed in frozen samples by ELISA methods (R&D Systems). Aortic PWV significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink