Etiology of lung cancer: Evidence from epidemiologic studies

Autor: Kaiyong Zou, Peiyuan Sun, Huang Huang, Haoran Zhuo, Ranran Qie, Yuting Xie, Jiajun Luo, Ni Li, Jiang Li, Jie He, Briseis Aschebrook-Kilfoy, Yawei Zhang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the National Cancer Center, Vol 2, Iss 4, Pp 216-225 (2022)
Druh dokumentu: article
ISSN: 2667-0054
DOI: 10.1016/j.jncc.2022.09.004
Popis: Lung cancer is one of the leading causes of cancer incidence and mortality worldwide. While smoking, radon, air pollution, as well as occupational exposure to asbestos, diesel fumes, arsenic, beryllium, cadmium, chromium, nickel, and silica are well-established risk factors, many lung cancer cases cannot be explained by these known risk factors. Over the last two decades the incidence of adenocarcinoma has risen, and it now surpasses squamous cell carcinoma as the most common histologic subtype. This increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future studies. Given the myriad exposures individuals experience in real-world settings, it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.
Databáze: Directory of Open Access Journals