Metastatic Multiple Myeloma to the Skin

Autor: Alex C. Holliday, Mohammed I. Khan, Sean E. Mazloom, Rahul N. Chavan, Douglas J. Grider
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Case Reports in Dermatological Medicine, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2090-6463
2090-6471
DOI: 10.1155/2019/7930123
Popis: Cutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of atypical plasma cells, positive for CD138 and CD45. In situ hybridization confirmed lambda light chain restriction. Despite rescue antimyeloma therapy with the anti-CD38 drug daratumumab, he rapidly declined clinically and succumbed to the disease four weeks after presentation. A standard treatment approach for cutaneous MM does not currently exist; however, various techniques to detect cytogenetic abnormalities are emerging and will provide additional prognostic value and direct individualized therapy.
Databáze: Directory of Open Access Journals
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