Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases

Autor: Kayeong Lim, Sung-Ik Cho, Jin-Soo Kim
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-27962-0
Popis: Base editing in nuclear DNA and mitochondrial DNA (mtDNA) is broadly useful for biomedical research, medicine, and biotechnology. Here the authors present zinc finger deaminases which catalyze targeted C-to-T base conversions without inducing unwanted indels in human cells.
Databáze: Directory of Open Access Journals