ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer
| Autor: | Antje M. Richter, Steffen Kiehl, Nicole Köger, Janina Breuer, Thorsten Stiewe, Reinhard H. Dammann |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Clinical Epigenetics, Vol 9, Iss 1, Pp 1-12 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1868-7075 1868-7083 |
| DOI: | 10.1186/s13148-017-0360-4 |
| Popis: | Abstract Background Lung cancer is the leading cause of cancer-related deaths with 1.8 million new cases each year and poor 5-year prognosis. Promoter hypermethylation of tumour suppressors leads to their inactivation and thereby can promote cancer development and progression. Results In this study, we analysed ZAR1 (zygote arrest 1), which has been said to be a maternal-effect gene and its expression mostly limited to certain reproductive tissues. Our study shows that ZAR1 is expressed in normal lung but inactivated by promoter methylation in lung cancer. ZAR1 is hypermethylated in primary lung cancer samples (22% small cell lung carcinoma (SCLC) and 76% non-small cell lung carcinoma (NSCLC), p |
| Databáze: | Directory of Open Access Journals |
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