A Review of Therapeutic Agents Given by Convection-Enhanced Delivery for Adult Glioblastoma

Autor: Nathaniel W. Rolfe, Nicholas B. Dadario, Peter Canoll, Jeffrey N. Bruce
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Pharmaceuticals, Vol 17, Iss 8, p 973 (2024)
Druh dokumentu: article
ISSN: 1424-8247
DOI: 10.3390/ph17080973
Popis: Glioblastoma remains a devastating disease with a bleak prognosis despite continued research and numerous clinical trials. Convection-enhanced delivery offers researchers and clinicians a platform to bypass the blood–brain barrier and administer drugs directly to the brain parenchyma. While not without significant technological challenges, convection-enhanced delivery theoretically allows for a wide range of therapeutic agents to be delivered to the tumoral space while preventing systemic toxicities. This article provides a comprehensive review of the antitumor agents studied in clinical trials of convection-enhanced delivery to treat adult high-grade gliomas. Agents are grouped by classes, and preclinical evidence for these agents is summarized, as is a brief description of their mechanism of action. The strengths and weaknesses of each clinical trial are also outlined. By doing so, the difficulty of untangling the efficacy of a drug from the technological challenges of convection-enhanced delivery is highlighted. Finally, this article provides a focused review of some therapeutics that might stand to benefit from future clinical trials for glioblastoma using convection-enhanced delivery.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje