| Autor: |
Pochanart Kanjan, Neha M. Sahasrabudhe, Bart J. de Haan, Paul de Vos |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 37, Iss , Pp 433-440 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.07.061 |
| Popis: |
Particulate β-glucans enhanced NF-κB expression in cell-lines co-expressing Dectin-1A-TLR4 and Dectin-1B-TLR4, while soluble β-glucans only synergistically acted on Dectin-1A-TLR4. This was different with Dectin-1 co-expressing TLR2 and TLR5, which inhibited activation after particulate and soluble β-glucan stimulation. The co-acting effect of extracellular TLR2, TLR4 and TLR5 and Dectin-1 by particulate and soluble β-glucan on cytokine production was confirmed in THP-1 macrophages. Dectin-1 activation by particulate β-glucans during TLR2 and TLR4 but not TLR5 blocking was shown to enhance the pro-inflammatory cytokines IL-6, IL-8 and TNF-α in THP-1 macrophages. This effect was stronger with particulate than with soluble β-glucan. The data demonstrate that β-glucans is an immune regulatory ligand for TLR2 and TLR4. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect