Fansidar drug induces cytotoxicity in some vital tissues in a rat model: combination defensive effect of selenium and zinc capsules
| Autor: | J. K Akintunde, J. A Ajiboye, E. O Siemuri, O. O. Olabisi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Drug Safety, Vol 12 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2042-0994 20420986 |
| DOI: | 10.1177/20420986211027101 |
| Popis: | Aim: Fansidar (FAN) is widely used as an antimalarial drug, but it may cause hepatoxicity, nephrotoxicity, and neurotoxicity. Hence, the study examines the cytoprotection of selenium (Se) and zinc (Zn) tablets against FAN induced toxicity. Method: Group I was given distilled water. Groups II, III, IV, and V received 50 mg/kg FAN by gavage. Group III was co-treated with a 50 mg/kg Se tablet. Group IV was co-treated with a 50 mg/kg Zn tablet. Group V was co-treated with a 50 mg/kg Se tablet + 50 mg/kg Zn tablet. The exposure lasted for 7 days (sub-acute exposure). Result: FAN causes cytotoxicity through significant ( p |
| Databáze: | Directory of Open Access Journals |
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